Dataset: Towards Eradication of HIV-1: Therapeutic Vaccination with the Peptide-Based Candidate Vacc-4x, 2014

Abstract

Human immunodeficiency virus (HIV)-1 infection continues to threaten global health with approximately 34 million adults and children living with HIV infection worldwide in 2010. Antiretroviral therapy (ART) has made a significant impact on HIV infection, however, since it cannot eradicate HIV, ART must be taken daily for life, thereby conferring a significant financial burden on healthcare services worldwide. The aim of this study was to test a cure against HIV by using Vacc-4x, a peptide-based therapeutic HIV vaccine. The study is registered at  www.clinicaltrials.gov.  

For further information about "Towards Eradication of HIV-1: Therapeutic Vaccination with the Peptide-Based Candidate Vacc-4x, 2014", please contact the principal investigator.

Variable Groups

Full Title

Towards Eradication of HIV-1: Therapeutic Vaccination with the Peptide-Based Candidate Vacc-4x, 2014

Identification Number

NSD2461

Authoring Entity

Name Affiliation
Sommerfelt, Maja A. Bionor Pharma AS

Producer

Name Affiliation Abbreviation Role
Sommerfelt, Maja A. Bionor Pharma AS BIONOR Principal Investigator

Copyright

Copyright (C) 2017 Bionor Pharma AS

Funding Agency/Sponsor

Name Abbreviation Role Grant
The Research Council of Norway RCN 220762

Data Distributor

Name Affiliation Abbreviation
NSD – Norwegian Centre for Research Data NSD

Version

Date: 2017-07-24

Notes

Original data from Maja A.Sommerfelt, Bionor Pharma AS are documented and prepared, first NSD-version.

Bibliographic Citation

"Towards Eradication of HIV-1: Therapeutic Vaccination with the Peptide-Based Candidate Vacc-4x, 2014". Data collected by Maja A.Sommerfelt, Bionor Pharma AS. First NSD edition, Bergen 2017.

List of Keywords

Topic Classification

Time Period Covered

Start End Cycle
2012 2017

Date of Collection

Start End Cycle
2012-12 2014-01

Country

Geographic Coverage

Country

Unit of Analysis

Individual

Universe

Persons between 18 and 63 years of age.

Kind of Data

Clinical data

Time Method

Cross-sectional survey

Data Collector

Sommerfelt, Maja A., Bionor Pharma AS  (BIONOR)

Sampling Procedure

33 participants between 18-63 years old. All patients participating in the study had previously received the vacc-4x vaccine in order to reduce the amount of HIV-1 virus in the blood and increase the immune response.

Mode of Data Collection

Clinical measurements

Availability Status

For further information about "Towards Eradication of HIV-1: Therapeutic Vaccination with the Peptide-Based Candidate Vacc-4x, 2014", please contact the principal investigator.

Restrictions

For further information about "Towards Eradication of HIV-1: Therapeutic Vaccination with the Peptide-Based Candidate Vacc-4x, 2014", please contact the principal investigator.

Related Publications

Delayed-type hypersensitivity responses to HIV Gag p24 relate to clinical outcome after peptide-based therapeutic immunization for chronic HIV infection

Kran A. M., Sommerfelt M. A., Baksaas I., Sørensen B., Kvale D. (2012) Delayed-type hypersensitivity responses to HIV Gag p24 relate to clinical outcome after peptide-based therapeutic immunization for chronic HIV infection. APMIS. 2012 Mar;120(3):204-9.

Intradermal vaccination of HIV-infected patients with short HIV Gag p24-like peptides induces CD4 + and CD8 + T cell responses lasting more than seven years

Lind A., Sommerfelt M. A., Holmberg J. O., Baksaas I., Sørensen B., Kvale D. (2012) Intradermal vaccination of HIV-infected patients with short HIV Gag p24-like peptides induces CD4 + and CD8 + T cell responses lasting more than seven years. Scand J Infect Dis. 2012 Aug;44(8):566-72.

Vacc-4x, a therapeutic vaccine comprised of four engineered peptides for the potential treatment of HIV infection

Jones T. (2010) Vacc-4x, a therapeutic vaccine comprised of four engineered peptides for the potential treatment of HIV infection. Curr Opin Investig Drugs. 2010 Aug;11(8):964-70.

Long-term HIV-specific responses and delayed resumption of antiretroviral therapy after peptide immunization targeting dendritic cells

Kran A. M., Sørensen B., Sommerfelt M. A., Nyhus J., Baksaas I., Kvale D. (2006) Long-term HIV-specific responses and delayed resumption of antiretroviral therapy after peptide immunization targeting dendritic cells. AIDS. 2006 Feb 28;20(4):627-30.

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