Dataset: zIPS Cells for Biomedicine: Zebrafish Pluripotent Stem Cells for Disease Modeling, 2015

Abstract

Despite the pre-eminence of mouse and human models of human disease through the generation of induced pluripotent stem cells, or iPS cells, several aspects of murine and human biology limit their use in high-throughput in vivo genetic screening. For these reasons, Zebrafish has become an attractive organism for developmentally and genetically tractable disease modeling. This project aimed to generate zebrafish embryo-derived cells suitable for biomedical applications and drug discovery. Specific aims were:  
1 - To generate pluripotent zebrafish ziPS cells by genetic and chemical reprogramming  
2 - To functionally characterize ziPS cells in vivo  
3 - To establish a proof-of-concept of the biomedical use of ziPS cells  
Strategy relies on expression of pluripotency factors into embryo-derived cells (zEDCs), and treatment with modifiers of the epigenome and of signaling pathways.  

For access to the dataset, use the NSD application form:  

http://www.nsd.uib.no/nsd/english/orderform.html

Variable Groups

Full Title

zIPS Cells for Biomedicine: Zebrafish Pluripotent Stem Cells for Disease Modeling, 2015

Identification Number

NSD2322

Authoring Entity

Name Affiliation
Collas, Philippe Institute of Basic Medical Sciences, University of Oslo

Producer

Name Affiliation Abbreviation Role
Collas, Philippe Institute of Basic Medical Sciences, University of Oslo UiO Principal Investigator

Copyright

Copyright (C) 2015 Philippe Collas, Institute of Basic Medical Sciences, University of Oslo

Funding Agency/Sponsor

Name Abbreviation Role Grant
The Research Council of Norway RCN 201593

Data Distributor

Name Affiliation Abbreviation
NSD – Norwegian Centre for Research Data NSD

Version

Date: 2016-05-31

Notes

Original data from Philippe Collas, Institute of Basic Medical Sciences, University of Oslo are documented and prepared, first NSD-version.

Bibliographic Citation

"zIPS Cells for Biomedicine: Zebrafish Pluripotent Stem Cells for Disease Modeling, 2015". Data collected by Philippe Collas, Institute of Basic Medical Sciences, University of Oslo. First NSD edition, Bergen 2016.

List of Keywords

Topic Classification

Time Period Covered

Start End Cycle
2010-12-31 2015-12-31

Date of Collection

Start End Cycle
2010-12-31 2015-12-31

Country

Norway  (NO)

Unit of Analysis

Other

Kind of Data

Other

Time Method

Time series

Data Collector

Collas, Philippe, Institute of Basic Medical Sciences, University of Oslo  (UiO)

Mode of Data Collection

Other

Location

Availability Status

Data from "zIPS Cells for Biomedicine: Zebrafish Pluripotent Stem Cells for Disease Modeling, 2015" are made available for research, teaching and students when ordered.

Extent of Collection

Several data files; different formats can be made.

Restrictions

Data from ”zIPS Cells for Biomedicine: Zebrafish Pluripotent Stem Cells for Disease Modeling, 2015" are made available for research, teaching and students when ordered.

Citation Requirement

Users are obliged to refer to producer and distributor of the data by writing the following in forewords or footnotes in eventual publications:
"(Some of) the data applied in the analysis in this publication are based on "zzIPS Cells for Biomedicine: Zebrafish Pluripotent Stem Cells for Disease Modeling, 2015". The survey was financed by The Reasearch Council of Norway. The data are provided by Philippe Collas, Institute of Basic Medical Sciences, University of Oslo  and prepared and made available by NSD – Norwegian Centre for Research Data. Neither Philippe Collas, Institute of Basic Medical Sciences, University of Oslo, The Research Council of Norway nor NSD are responsible for the analysis/interpretation of the data presented here.

Deposit Requirement

Access to data is given on the condition that NSD gets a PDF-file of eventual reports that are written on the basis of the data. This to ensure best possible information of the use of data we distribute.

Conditions

The order form has to include name, institutional affiliation, project title, information about sources of financing and postal address. A declaration of secrecy has to be signed before delivery of data.

Disclaimer

Neither Philippe Collas, Institute of Basic Medical Sciences, University of Oslo, The Research Council of Norway nor NSD are responsible for the analysis/interpretation of the data presented here.

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