Dataset: Transmaternal Exposure to Bisphenol A and Phthalates and the Development of Type 1 Diabetes, 2015

Abstract

The Scandinavian countries have the highest prevalence of type 1 diabetes in the world with a steady increase in Norway of 600 new cases yearly. Type 1 diabetes mellitus (T1DM) is an autoimmune insulin deficiency due to destruction of insulin producing beta-cells. It is the most common type of diabetes in children and is induced by various environmental factors acting on a genetic predisposition. There is a parallel occurrence of increased diabetes prevalence and a high exposure burden of endocrine disruptors (EDs), leaking from consumer products, over the last decades. Continuous presence of these chemicals in urine from adults, children and even infants reflects a constant exposure to EDs. The aim of the project was to investigate the effect of EDs on the development of T1DM. We investigated the effect of combined exposure to some of the most commonly found EDs, bisphenol A, di(2-ethylhexyl) phthalate (DEHP), diisobuthyl phthalate (DIBP), dibuthyl phthalate (DBP) and benzyl buthyl phthalate (BBP), in a mouse model for T1DM. Non obese diabetic (NOD) mice spontaneously develop T1DM and we monitored if the selected endocrine disruptors had an impact on the time of onset and incidence of the disease. To enable fetal and early life exposure we exposed pregnant and lactating mice. Progression of T1DM in pups was monitored through measurements of blood glucose, autoantibodies, proinflammatory cytokines and immuno-phenotyping of peripheral lymph nodes. The degree of insulitis in the pancreas and the amount of apoptotic beta cells was evaluated. Furthermore, the mechanisms involved in beta-cell death were investigated ex vivo in pancreatic islets and in a beta cell-line in vitro. The knowledge gained in this project will help to improve toxicological evaluations and health hazard assessment of EDs since there is limited knowledge on immunological effects of transmaternal exposure to a combination of these chemicals.

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http://www.nsd.uib.no/nsd/english/orderform.html

Variable Groups

Full Title

Transmaternal Exposure to Bisphenol A and Phthalates and the Development of Type 1 Diabetes, 2015

Identification Number

NSD2328

Authoring Entity

Name Affiliation
Bodin, Johanna Division of Environmental Medicine, The Norwegian Institute of Public Health

Producer

Name Affiliation Abbreviation Role
Bodin, Johanna Division of Environmental Medicine, The Norwegian Institute of Public Health FHI

Copyright

Copyright (C) 2015 Johanna Bodin, Division of Environmental Medicine, The Norwegian Institute of Public Health

Funding Agency/Sponsor

Name Abbreviation Role Grant
The Research Council of Norway RCN 213060

Data Distributor

Name Affiliation Abbreviation
NSD – Norwegian Centre for Research Data NSD

Version

Date: 2016-06-21

Notes

Original data from Johanna Bodin, Division of Environmental Medicine, The Norwegian Institute of Public Health are documented and prepared, first NSD-version.

Bibliographic Citation

"Transmaternal Exposure to Bisphenol A and Phthalates and the Development of Type 1 Diabetes, 2015". Data collected by Johanna Bodin, Division of Environmental Medicine, The Norwegian Institute of Public Health. First NSD edition, Bergen 2016.

List of Keywords

Topic Classification

Time Period Covered

Start End Cycle
2012-01-02 2015-01-31

Date of Collection

Start End Cycle
2012-01-02 2015-01-31

Country

Norway  (NO)

Unit of Analysis

Other

Kind of Data

Other

Time Method

Time series

Data Collector

Bodin, Johanna, Division of Environmental Medicine, The Norwegian Institute of Public Health  (NIPH)

Mode of Data Collection

Other

Location

Availability Status

Data from "Transmaternal Exposure to Bisphenol A and Phthalates and the Development of Type 1 Diabetes, 2015" are made available for research, teaching and students when ordered.

Extent of Collection

23 data files; different formats can be made.

Restrictions

Data from ”Transmaternal Exposure to Bisphenol A and Phthalates and the Development of Type 1 Diabetes, 2015” are made available for research, teaching and students when ordered.

Citation Requirement

Users are obliged to refer to producer and distributor of the data by writing the following in forewords or footnotes in eventual publications:
"(Some of) the data applied in the analysis in this publication are based on "Transmaternal Exposure to Bisphenol A and Phthalates and the Development of Type 1 Diabetes, 2015". The survey was financed by The Reasearch Council of Norway. The data are provided by Johanna Bodin, Division of Environmental Medicine, The Norwegian Institute of Public Health and prepared and made available by NSD – Norwegian Centre for Research Data. Neither Johanna Bodin, Division of Environmental Medicine, The Norwegian Institute of Public Health, The Research Council of Norway nor NSD are responsible for the analysis/interpretation of the data presented here.

Deposit Requirement

Access to data is given on the condition that NSD gets a PDF-file of eventual reports that are written on the basis of the data. This to ensure best possible information of the use of data we distribute.

Conditions

The order form has to include name, institutional affiliation, project title, information about sources of financing and postal address. A declaration of secrecy has to be signed before delivery of data.

Disclaimer

Neither Johanna Bodin, Division of Environmental Medicine, The Norwegian Institute of Public Health, The Research Council of Norway nor NSD are responsible for the analysis/interpretation of the data presented here.

Related Publications

Long-term Bisphenol A Exposure Accelerates Insulitis Development in Diabetes-Prone NOD Mice

Bodin, J. Bølling, A. K. Samuelsen, M. Becher, R. Løvik, M. Nygaard, U.C. (2013). Long-term Bisphenol A Exposure Accelerates Insulitis Development in Diabetes-Prone NOD Mice, Immunopharmacology and Immunotoxicology, Early Online: 1–10.

DOI: 10.3109/08923973.2013.772195

Transmaternal Bisphenol A Exposure Accelerates Diabetes Type 1 Development in NOD Mice

Bodin, J. Bølling, A.K. Becher, R. Kuper, F. Løvik, M. Nygaard, U.C. (2014). Transmaternal Bisphenol A Exposure Accelerates Diabetes Type 1 Development in NOD Mice, Toxicological Sciences 137(2), 311–323 2014.

Doi: 10.1093/toxsci/kft242

Exposure to Bisphenol A, But Not Phthalates, Increasesspontaneous Diabetes Type 1 Development in NOD Mice

Bodin, J. Bølling, A.K. Wendt, A. Eliasson, L. Becher, R. Kuper, F. Løvik, M. Nygaard, U.C. (2015). Exposure to Bisphenol A, But Not Phthalates, Increasesspontaneous Diabetes Type 1 Development in NOD Mice, Toxicology Reports 2 (2015) 99-110.

Doi:10.1016/j.toxrep.2015.02.010

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