Dataset: Polymorphisms in the Vitamin D System and Health, 2013

Abstract

Vitamin D is produced in the skin after sun exposure or obtained from food, mainly fatty fish or vitamin D supplements. For activation vitamin D must be hydroxylated in the liver to 25(OH)D and thereafter in the kidney to 1,25(OH)2D. For 1,25(OH)2D to exert its effect it has to bind to the vitamin D receptor (VDR). The serum level of 25(OH)D is in part genetically determined and several polymorphisms with effects on serum 25(OH)D have been identified. These polymorphisms appear as important for the serum 25(OH)D level as the effect of season, or vitamin D supplementation. Vitamin D is not only vital for the skeleton, but appears also to be related to heart disease, diabetes, cancer and mortality. However, as the serum level of 25(OH)D is strongly influenced by lifestyle factors that are also related to health outcomes, it is difficult to decide whether the relation between vitamin D and health is causal or not. On the other hand, the polymorphisms are not influenced by life-style, and the effect of the polymorphisms will be life-long. Accordingly, they may be a better marker of vitamin D status than a single serum 25(OH)D measurement. Furthermore, there are a number of polymorphisms regarding the VDR that may be associated with health. In the Tromsø study DNA is available from almost 27,000 individuals, and end-point registers have been made for fractures, coronary infarction, diabetes, cancer and mortality. In the present study we therefore related the polymorphisms affecting the serum 25(OH)D level and the function of the VDR with these endpoints with the use of a case-cohort design. If we were to find the expected associations between the polymorphisms and diseases, this would further strengthen the role of vitamin D in human health, and may have importance for recommendations regarding vitamin D supplementation. Considering the high prevalence of vitamin D deficiency worldwide, this could potentially have huge consequences for public health.

For further information about ”Polymorphisms in the Vitamin D System and Health, 2013”, please contact the principal investigator.

Variable Groups

Full Title

Polymorphisms in the Vitamin D System and Health, 2013

Identification Number

NSD2368

Authoring Entity

Name Affiliation
Jorde, Rolf University of Tromsø - The Arctic University of Norway

Producer

Name Affiliation Abbreviation Role
Jorde, Rolf University of Tromsø - The Arctic University of Norway UiT Principal Investigator

Copyright

Copyright (C) 2013 Rolf Jorde, UiT

Funding Agency/Sponsor

Name Abbreviation Role Grant
The Research Council of Norway RCN 213787

Data Distributor

Name Affiliation Abbreviation
NSD – Norwegian Centre for Research Data NSD

Version

Date: 2016-12-13

Notes

Original data from Rolf Jorde, UiT are documented and prepared, first NSD-version.

Bibliographic Citation

"Polymorphisms in the Vitamin D System and Health, 2013". Data collected by Rolf Jorde, UiT. First NSD edition, Bergen 2016.

List of Keywords

Topic Classification

Time Period Covered

Start End Cycle
2012-09-01 2015-08-31

Date of Collection

Start End Cycle
1994-01-01 2013-07-01

Country

Norway  (NO)

Geographic Coverage

County

Unit of Analysis

Individual

Universe

Participants in the Tromsø study from 1994 to 2009, number 4, 5 and 6.

Kind of Data

Other

Time Method

Cohort study

Data Collector

Jorde, Rolf, UiT Norges arktiske universitet  (UiT)

Sampling Procedure

Gross sample: 26 500 persons
Net sample: 13 500 persons

Mode of Data Collection

Paper/pencil questionnaire

Availability Status

For further information about "Polymorphisms in the Vitamin D System and Health, 2013", please contact the principal investigator.

Restrictions

For further information about "Polymorphisms in the Vitamin D System and Health, 2013", please contact the principal investigator.

Conditions

For further information about "Polymorphisms in the Vitamin D System and Health, 2013", please contact the principal investigator.

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